By Dr. Taylor, Aesthetic Medicine Specialist 
In the evolving world of non-surgical aesthetics, two Korean innovations are gaining global recognition for their skin-rejuvenating power: Juvelook and Rejuran. Both are injectable treatments designed to improve skin quality from within, but they work differently—and are best suited for different skin goals.
In this article, we’ll break down how Juvelook and Rejuran compare, their key benefits, who they’re best for, and whether you should choose one—or both.
What Is Juvelook?
Juvelook is a next-generation hybrid skin booster that combines hyaluronic acid (HA) with poly-D,L-lactic acid (PDLLA) to provide both instant hydration and long-term skin rejuvenation. Originally developed in South Korea, Juvelook has quickly gained popularity in aesthetic medicine for its dual-action approach: it plumps and hydrates the skin immediately, while also stimulating collagen production over time for firmer, smoother, more youthful skin.
How It Works
- Hyaluronic Acid (HA): Delivers immediate hydration and glow by attracting water molecules into the skin. It helps improve elasticity and texture from the first session.
- PDLLA (Poly-D,L-Lactic Acid): Acts as a biostimulator, activating fibroblasts to produce new collagen over several weeks. This gradually enhances skin firmness and reduces fine lines, pores, and laxity.
The PDLLA is suspended in a gel-like HA base, so Juvelook gives a visible improvement right away, while continuing to build internal structure for months.
What Juvelook Treats
- Fine lines and wrinkles
- Enlarged pores
- Acne scarring and texture irregularities
- Volume loss in delicate areas (under-eyes, temples, cheeks)
- Skin dullness or early signs of aging
It’s safe for use in sensitive areas where traditional fillers may be too thick or risky—making it a great option for first-time injectable patients.
Treatment Protocol & Results
- Sessions: Typically 2–3 sessions spaced 3–4 weeks apart.
- Visible results: Initial glow after 1 session; collagen stimulation peaks around 6–8 weeks.
- Longevity: Results can last 12–18 months, depending on lifestyle and number of treatments.
Juvelook is praised for delivering a natural, healthy look—not an overfilled one.
Key Benefits
- Immediate hydration + long-term collagen boost
- Improves texture, tone, and elasticity
- Minimal downtime (1–3 days of mild swelling or redness)
- Biodegradable and biocompatible with skin
- Approved by KFDA and CE (EU); gaining global recognition
Juvelook is ideal if you’re looking for a refreshed, firmer, and glowing complexion—with both short-term and lasting effects. It sits somewhere between a skin booster and a soft filler, offering the best of both worlds for subtle, rejuvenated skin.
What Is Rejuran?
Rejuran is a regenerative skin treatment that uses polynucleotides (PN)—highly purified DNA fragments derived from salmon—to repair, heal, and rejuvenate the skin at a cellular level. It’s often referred to as the “salmon DNA facial”, and it’s especially popular in South Korea and other parts of Asia for its gentle, natural approach to skin rejuvenation.
Unlike traditional fillers or even collagen-boosting injectables like Juvelook, Rejuran focuses on restoring skin health, making it ideal for sensitive, inflamed, or damaged skin.
How It Works
- Polynucleotides (PN) are long-chain molecules of DNA that enhance skin regeneration by:
- Stimulating fibroblast activity to produce collagen and elastin
- Improving microcirculation and nutrient delivery
- Calming inflammation and supporting tissue healing
- Strengthening the skin barrier
Because salmon DNA is structurally similar to human DNA (~95–97%), it integrates safely and effectively into the skin.
What Rejuran Treats
- Skin sensitivity and inflammation
- Redness, rosacea, or post-acne healing
- Enlarged pores and uneven tone
- Early signs of aging (fine lines, laxity)
- Damaged skin from laser treatments, peels, or sun exposure
- Shallow acne scarring
Rejuran is not used to add volume—instead, it repairs and strengthens your existing skin tissue from the inside out.
Treatment Protocol & Results
- Sessions: 3–4 treatments spaced 2–4 weeks apart
- Visible results: Improvements in texture and calmness appear within 1–2 weeks
- Maintenance: Every 4–6 months for sustained benefits
- Longevity: Effects last 4–6 months but can build with consistent use
The procedure is typically done using micro-injections or papule technique, leaving small bumps that disappear in 24–72 hours.
Key Benefits
- Deep tissue healing and skin regeneration
- Reduces inflammation, redness, and sensitivity
- Improves elasticity and texture
- Enhances natural glow without altering facial volume
- Safe for all skin types, including acne-prone or post-laser skin
- Minimal downtime; no risk of overfilling or lumps
In Short
Rejuran is like a reset button for your skin. It doesn’t fill or plump—it heals. It’s perfect for people who want to improve their skin’s resilience, texture, and clarity without drastic changes. Think of it as cellular therapy for tired or stressed-out skin.
Rejuran vs Juvelook: Side-by-Side Comparison
Here’s a detailed side‑by‑side comparison of Juvelook and Rejuran, highlighting their key differences, benefits, mechanisms, and ideal use cases:
Juvelook vs Rejuran: At a Glance
| Feature | Juvelook | Rejuran |
|---|---|---|
| Core Ingredients | Hyaluronic Acid (HA) + Poly‑D,L‑Lactic Acid (PDLLA) | Polynucleotides (salmon DNA fragments, PDRN) |
| Mechanism of Action | Hydrates skin instantly; PDLLA stimulates neocollagenesis for volume and firmness | Enhances skin regeneration, barrier repair, collagen and elastin via PN |
| Primary Benefits | Smoother texture, reduced fine lines, natural volumizing, glow, elasticity | Healing of compromised skin, improved elasticity, texture, pore reduction, calmer complexion |
| Ideal For… | Restoring youthfulness through lift and subtle volume (e.g., under-eye, cheeks) | Sensitive or inflamed skin, post-treatment recovery, strengthening skin barrier |
| Result Timeline | Immediate hydration; visible improvement over weeks and months | Subtle improvements within 2–4 weeks, building over sessions |
| Duration of Effects | Up to 12–18 months, thanks to collagen-building effects | Usually lasts around 6–9 months, with maintenance recommended |
| Treatment Protocol | Several sessions (e.g., 2–3) spaced ~3–4 weeks apart | Typically 3 sessions spaced 2–4 weeks apart + maintenance every 6 months |
| Common Side Effects | Mild redness, swelling, bruising or tenderness | Similar: swelling, redness, slight injection-site sensitivity |
What Stands Out
Juvelook delivers a twofold effect—instant hydration plus gradual build-up of collagen for structural lift and firmness. Great for enhancing youthfulness and volume in delicate areas. It’s ideal if you’re targeting plumping, lifting, and smoothing in one treatment.
Rejuran, on the flip side, focuses on cell-level skin healing—boosting resilience and clarity, especially in compromised or sensitive skin. It’s more about repairing and strengthening.
Overlay Summary
- Structural vs. Regenerative: Juvelook builds structure via collagen; Rejuran regenerates from within via DNA-based repair.
- Volume vs. Barrier: Juvelook adds subtle volume and lift, Rejuran heals and refreshes the skin barrier.
- Immediate vs. Gradual: Juvelook gives immediate glow plus gradual enhancement; Rejuran unfolds more subtly over time.
- Longer vs. Medium Duration: Juvelook can last much longer (12–18 months), whereas Rejuran generally requires more frequent maintenance.
Which Treatment Should You Choose?
- Want Hydration + Youthful Volume? → Choose Juvelook
Juvelook combines Hyaluronic Acid (HA) with Poly‑D,L‑Lactic Acid (PDLLA). It delivers instant hydration through HA, while PDLLA gently stimulates long-term collagen production for firmer skin, improved elasticity, and reduced wrinkles or acne scarring. Great for those looking for a glowing, lifted, youthful appearance.
- Need to Heal and Repair Sensitive or Damaged Skin? → Choose Rejuran
Rejuran uses polynucleotides (PNs) derived from salmon DNA. It focuses on cellular regeneration—improving the skin barrier, reducing inflammation, and repairing damage. Ideal for inflamed, post-acne, or post-procedure skin.
- Looking for Fast Results vs. Gentle Gradual Change?
Juvelook tends to deliver more visible improvements quickly due to its dual-action hydration and collagen-stimulation.
Rejuran builds results more subtly, focusing on improving texture and resilience over a few weeks.
- Longer-Lasting Results? → Go with Juvelook
Juvelook results can last up to 12–18 months, thanks to its collagen-stimulating effect.
Rejuran typically lasts 6–9 months per treatment cycle and may require more frequent maintenance.
- Sensitive Skin or Post-Treatment Recovery? → Rejuran
Its regenerative and soothing properties make Rejuran excellent for calming irritated or sensitive skin, while accelerating healing after procedures like laser treatments or peels.
- Want Both Firming & Healing? → Consider Combining Both
For comprehensive rejuvenation, many clinics recommend a dual-protocol:
- Start with Rejuran to repair and strengthen the skin barrier.
- Follow with Juvelook to add collagen, lift, and hydration.
Final Thoughts
When it comes to choosing between Juvelook and Rejuran, the best decision starts with understanding your skin’s needs. Juvelook builds structure and youthfulness; Rejuran repairs and calms. Together or alone, both treatments offer natural-looking results and long-term skin improvement with minimal downtime.
For optimal results, consult a licensed aesthetic provider who can tailor the treatment to your skin goals. Whether you want to restore your glow, heal your skin, or do both—there’s a modern solution waiting for you.
Sources:
- https://www.koreabeautytech.com/blogs/news/juvelook-vs-rejuran-3-key-differences-you-should-know-now
- https://vslineclinic.com/pages/inj-skinbooster
- https://www.medicadepot.com/blog/rejuran-vs-juvelook.html